ERLIN1 [The Human Chemical-Genetic Interaction Map Project]

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======= ERLIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERLIN1
  * **<color #00a2e8>Official Name</color>**: ER lipid raft associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10613|10613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75477|O75477]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERLIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERLIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611604|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:24217618}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cholesterol metabolic process|
|negative regulation of sterol biosynthetic process|
|negative regulation of cholesterol biosynthetic process|
|SREBP signaling pathway|
|cellular response to sterol depletion|
|response to sterol depletion|
|negative regulation of alcohol biosynthetic process|
|negative regulation of fatty acid biosynthetic process|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|negative regulation of fatty acid metabolic process|
|ER-nucleus signaling pathway|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|regulation of fatty acid biosynthetic process|
|negative regulation of lipid biosynthetic process|
|cholesterol binding|
|regulation of cholesterol metabolic process|
|ubiquitin-dependent ERAD pathway|
|regulation of alcohol biosynthetic process|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|regulation of steroid biosynthetic process|
|ERAD pathway|
|negative regulation of small molecule metabolic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|response to endoplasmic reticulum stress|
|steroid metabolic process|
|ubiquitin protein ligase binding|
|alcohol metabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|proteolysis|
|transmembrane transport|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.47|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.1|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.85|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.83|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.84|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERLIN1 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>