ERLIN1

Gene Information

Official Symbol: ERLIN1
Official Name: ER lipid raft associated 1
Aliases and Previous Symbols: N/A
Entrez ID: 10613
UniProt: O75477
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016].
UniProt Summary: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:24217618}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-2.47
Epothilone-B 0.0015μM R05 exp231	-2.1
CVT-10216 0.1μM R06 exp278	-1.85
Staurosporine 0.02μM R08 exp524	-1.83
Bortezomib 0.005μM R00 exp6	1.84
BI-2536 0.02μM R03 exp96	2.48

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17445
Expression level (log2 read counts): 6.64

Expression Distribution

negative regulation of cholesterol metabolic process
negative regulation of sterol biosynthetic process
negative regulation of cholesterol biosynthetic process
SREBP signaling pathway
cellular response to sterol depletion
response to sterol depletion
negative regulation of alcohol biosynthetic process
negative regulation of fatty acid biosynthetic process
negative regulation of steroid biosynthetic process
negative regulation of steroid metabolic process
negative regulation of fatty acid metabolic process
ER-nucleus signaling pathway
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
regulation of fatty acid biosynthetic process
negative regulation of lipid biosynthetic process
cholesterol binding
regulation of cholesterol metabolic process
ubiquitin-dependent ERAD pathway
regulation of alcohol biosynthetic process
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
regulation of steroid biosynthetic process
ERAD pathway
negative regulation of small molecule metabolic process
regulation of steroid metabolic process
cholesterol metabolic process
secondary alcohol metabolic process
sterol metabolic process
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
response to endoplasmic reticulum stress
steroid metabolic process
ubiquitin protein ligase binding
alcohol metabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process