ERP29
Gene Information
- Official Symbol: ERP29
- Official Name: endoplasmic reticulum protein 29
- Aliases and Previous Symbols: N/A
- Entrez ID: 10961
- UniProt: P30040
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
Pfam Domains GO Terms
Pfam Domains
| ERp29 |
| ERp29 N |
GO Terms
| protein unfolding |
| protein disulfide isomerase activity |
| smooth endoplasmic reticulum |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| regulation of response to endoplasmic reticulum stress |
| transport vesicle |
| melanosome |
| chaperone binding |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| activation of MAPK activity |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of intrinsic apoptotic signaling pathway |
| protein localization to extracellular region |
| peptide secretion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| negative regulation of secretion by cell |
| protein folding |
| negative regulation of secretion |
| positive regulation of MAP kinase activity |
| endoplasmic reticulum lumen |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of apoptotic signaling pathway |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| cell surface |
| positive regulation of transferase activity |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| protein homodimerization activity |
| regulation of transferase activity |
| intracellular protein transport |
| secretion by cell |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14991
- Expression level (log2 read counts): 7.99
Expression Distribution
ERP29 Expression in NALM6 Cells: 7.99
