ESCO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ESCO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESCO1
  * **<color #00a2e8>Official Name</color>**: establishment of sister chromatid cohesion N-acetyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114799|114799]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5FWF5|Q5FWF5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESCO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESCO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609674|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein acetylation|
|peptide-lysine-N-acetyltransferase activity|
|N-acetyltransferase activity|
|acetyltransferase activity|
|sister chromatid cohesion|
|regulation of DNA replication|
|chromatin|
|peptidyl-lysine acetylation|
|chromosome|
|sister chromatid segregation|
|protein acetylation|
|protein acylation|
|nuclear chromosome segregation|
|chromosome segregation|
|peptidyl-lysine modification|
|post-translational protein modification|
|zinc ion binding|
|peptidyl-amino acid modification|
|cell cycle process|
|chromosome organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.15|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.87|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.84|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.78|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.75|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pds5b|PDS5B]]|0.563|
|[[:human genes:a:anp32a|ANP32A]]|0.468|
|[[:human genes:c:cnot2|CNOT2]]|0.456|
|[[:human genes:p:psme3|PSME3]]|0.45|
|[[:human genes:k:kdm6a|KDM6A]]|0.423|
|[[:human genes:p:ppm1d|PPM1D]]|0.416|
|[[:human genes:c:cnot3|CNOT3]]|0.413|
|[[:human genes:i:ints8|INTS8]]|0.41|
|[[:human genes:a:arid4b|ARID4B]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18229
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESCO1 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>