ESD [The Human Chemical-Genetic Interaction Map Project]

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======= ESD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESD
  * **<color #00a2e8>Official Name</color>**: esterase D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2098|2098]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10768|P10768]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/133280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Esterase|
|Abhydrolase 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|S-formylglutathione hydrolase activity|
|methylumbelliferyl-acetate deacetylase activity|
|formaldehyde catabolic process|
|formaldehyde metabolic process|
|cellular detoxification of aldehyde|
|hydrolase activity, acting on ester bonds|
|cellular response to aldehyde|
|aldehyde catabolic process|
|glutathione derivative biosynthetic process|
|glutathione derivative metabolic process|
|carboxylic ester hydrolase activity|
|antibiotic catabolic process|
|cellular aldehyde metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|detoxification|
|sulfur compound biosynthetic process|
|cellular response to toxic substance|
|cytoplasmic vesicle|
|endoplasmic reticulum lumen|
|sulfur compound metabolic process|
|small molecule catabolic process|
|drug metabolic process|
|response to toxic substance|
|cellular response to oxygen-containing compound|
|identical protein binding|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.28|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.8|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESD Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>