ESD

Entrez Summary: N/A
UniProt Summary: Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Esterase
Abhydrolase 5

S-formylglutathione hydrolase activity
methylumbelliferyl-acetate deacetylase activity
formaldehyde catabolic process
formaldehyde metabolic process
cellular detoxification of aldehyde
hydrolase activity, acting on ester bonds
cellular response to aldehyde
aldehyde catabolic process
glutathione derivative biosynthetic process
glutathione derivative metabolic process
carboxylic ester hydrolase activity
antibiotic catabolic process
cellular aldehyde metabolic process
cellular detoxification
antibiotic metabolic process
detoxification
sulfur compound biosynthetic process
cellular response to toxic substance
cytoplasmic vesicle
endoplasmic reticulum lumen
sulfur compound metabolic process
small molecule catabolic process
drug metabolic process
response to toxic substance
cellular response to oxygen-containing compound
identical protein binding
organonitrogen compound biosynthetic process
response to oxygen-containing compound
small molecule metabolic process
organic substance catabolic process
cellular catabolic process