ESF1 [The Human Chemical-Genetic Interaction Map Project]

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======= ESF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESF1
  * **<color #00a2e8>Official Name</color>**: ESF1 nucleolar pre-rRNA processing protein homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51575|51575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H501|Q9H501]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618765|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUC153|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|extracellular space|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.73|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.7|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.76|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.82|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:twistnb|TWISTNB]]|0.446|
|[[:human genes:r:rps9|RPS9]]|0.443|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.435|
|[[:human genes:d:ddtl|DDTL]]|0.435|
|[[:human genes:a:akirin2|AKIRIN2]]|0.43|
|[[:human genes:r:rrp15|RRP15]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.416|
|[[:human genes:p:psmb4|PSMB4]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:h:hap1|HAP1]]|0.407|
|[[:human genes:p:psmd2|PSMD2]]|0.407|
|[[:human genes:c:c14orf93|C14orf93]]|0.406|
|[[:human genes:w:wdr87|WDR87]]|0.404|
|[[:human genes:r:rps7|RPS7]]|0.402|
|[[:human genes:s:sf3a3|SF3A3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 470/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|21/28|
|bone|17/26|
|breast|16/33|
|central nervous system|31/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|12/21|
|liver|11/20|
|lung|54/75|
|lymphocyte|12/16|
|ovary|17/26|
|pancreas|19/24|
|peripheral nervous system|10/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|13/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1794
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESF1 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>