ESR2

Entrez Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
PRPF8	0.451
HGC6.3	0.428

estrogen response element binding
estrogen receptor activity
intracellular estrogen receptor signaling pathway
receptor antagonist activity
steroid binding
nuclear receptor activity
steroid hormone receptor activity
negative regulation of signaling receptor activity
intracellular steroid hormone receptor signaling pathway
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
regulation of signaling receptor activity
transcription initiation from RNA polymerase II promoter
negative regulation of cell growth
cellular response to steroid hormone stimulus
DNA-templated transcription, initiation
negative regulation of growth
positive regulation of DNA-binding transcription factor activity
transcription coactivator activity
response to steroid hormone
enzyme binding
regulation of cell growth
regulation of DNA-binding transcription factor activity
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of growth
DNA-binding transcription factor activity
zinc ion binding
response to lipid
negative regulation of transcription by RNA polymerase II
response to hormone
response to organic cyclic compound
identical protein binding