ETAA1

Gene Information

Official Symbol: ETAA1
Official Name: ETAA1 activator of ATR kinase
Aliases and Previous Symbols: N/A
Entrez ID: 54465
UniProt: Q9NY74
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.6
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.5
Deferoxamine 11μM R07 exp350	-2.19
Ibrutinib 10μM R08 exp442	-1.71
Nutlin-3A 1.6μM R06 exp294	1.86

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5095
Expression level (log2 read counts): 5.03

Expression Distribution

nuclear replication fork
regulation of DNA damage checkpoint
protein serine/threonine kinase activator activity
replication fork processing
regulation of cell cycle checkpoint
DNA-dependent DNA replication maintenance of fidelity
DNA-dependent DNA replication
DNA replication
regulation of response to DNA damage stimulus
positive regulation of protein serine/threonine kinase activity
DNA repair
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
regulation of cell cycle
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of response to stress
regulation of phosphorylation
positive regulation of cellular protein metabolic process
cellular response to stress
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process