ETV2 [The Human Chemical-Genetic Interaction Map Project]

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======= ETV2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETV2
  * **<color #00a2e8>Official Name</color>**: ETS variant transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2116|2116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00321|O00321]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETV2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETV2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BMP signaling pathway involved in mesodermal cell fate specification|
|regulation of transcription involved in primary germ layer cell fate commitment|
|positive regulation of mesoderm development|
|mesodermal cell fate specification|
|mesodermal cell fate commitment|
|positive regulation of endothelial cell differentiation|
|regulation of transcription involved in cell fate commitment|
|regulation of mesoderm development|
|mesodermal cell differentiation|
|cell fate commitment involved in formation of primary germ layer|
|regulation of endothelial cell differentiation|
|positive regulation of epithelial cell differentiation|
|mesoderm formation|
|mesoderm morphogenesis|
|erythrocyte differentiation|
|cell fate specification|
|erythrocyte homeostasis|
|BMP signaling pathway|
|blastocyst development|
|cellular response to BMP stimulus|
|response to BMP|
|myeloid cell homeostasis|
|formation of primary germ layer|
|mesoderm development|
|Notch signaling pathway|
|regulation of epithelial cell differentiation|
|placenta development|
|gastrulation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|homeostasis of number of cells|
|myeloid cell differentiation|
|cell fate commitment|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|blood vessel development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|response to growth factor|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|enzyme linked receptor protein signaling pathway|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETV2 Expression in NALM6 Cells: -1.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>