ETV2
Gene Information
- Official Symbol: ETV2
- Official Name: ETS variant transcription factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2116
- UniProt: O00321
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Ets |
GO Terms
| BMP signaling pathway involved in mesodermal cell fate specification |
| regulation of transcription involved in primary germ layer cell fate commitment |
| positive regulation of mesoderm development |
| mesodermal cell fate specification |
| mesodermal cell fate commitment |
| positive regulation of endothelial cell differentiation |
| regulation of transcription involved in cell fate commitment |
| regulation of mesoderm development |
| mesodermal cell differentiation |
| cell fate commitment involved in formation of primary germ layer |
| regulation of endothelial cell differentiation |
| positive regulation of epithelial cell differentiation |
| mesoderm formation |
| mesoderm morphogenesis |
| erythrocyte differentiation |
| cell fate specification |
| erythrocyte homeostasis |
| BMP signaling pathway |
| blastocyst development |
| cellular response to BMP stimulus |
| response to BMP |
| myeloid cell homeostasis |
| formation of primary germ layer |
| mesoderm development |
| Notch signaling pathway |
| regulation of epithelial cell differentiation |
| placenta development |
| gastrulation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| homeostasis of number of cells |
| myeloid cell differentiation |
| cell fate commitment |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| in utero embryonic development |
| blood vessel morphogenesis |
| reproductive structure development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| blood vessel development |
| cellular response to growth factor stimulus |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| response to growth factor |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| enzyme linked receptor protein signaling pathway |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| cell-cell signaling |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13401
- Expression level (log2 read counts): -1.04
Expression Distribution
ETV2 Expression in NALM6 Cells: -1.04
