EVPL

Entrez Summary: This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016].
UniProt Summary: Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Deguelin 0.15μM R05 exp209	-1.72
PFI-3 10μM R03 exp144	1.79

intermediate filament binding
desmosome
intermediate filament cytoskeleton
intermediate filament cytoskeleton organization
intermediate filament-based process
peptide cross-linking
cornified envelope
protein binding, bridging
cornification
intermediate filament
structural molecule activity
keratinization
keratinocyte differentiation
cadherin binding
epidermal cell differentiation
skin development
epidermis development
wound healing
response to wounding
epithelial cell differentiation
programmed cell death
cell death
cytoskeleton organization
epithelium development
tissue development
membrane