EXD2

Gene Information
  • Official Symbol: EXD2
  • Official Name: exonuclease 3'-5' domain containing 2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 55218
  • UniProt: Q9NVH0
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. {ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:26807646}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 12483
  • Expression level (log2 read counts): -0.25

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1