EXOC5 [The Human Chemical-Genetic Interaction Map Project]

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======= EXOC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOC5
  * **<color #00a2e8>Official Name</color>**: exocyst complex component 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10640|10640]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00471|O00471]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604469|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ral GTPase binding|
|exocyst|
|establishment of planar polarity|
|establishment of tissue polarity|
|epithelial cell apoptotic process|
|morphogenesis of a polarized epithelium|
|non-motile cilium assembly|
|Golgi to plasma membrane transport|
|vesicle docking|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|protein N-terminus binding|
|midbody|
|organelle localization by membrane tethering|
|membrane docking|
|protein localization to plasma membrane|
|protein localization to cell periphery|
|cilium assembly|
|cilium organization|
|Golgi vesicle transport|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|tissue morphogenesis|
|organelle localization|
|organelle assembly|
|exocytosis|
|apoptotic process|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell death|
|epithelium development|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|tissue development|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:exoc4|EXOC4]]|0.483|
|[[:human genes:e:exoc3|EXOC3]]|0.449|
|[[:human genes:t:thg1l|THG1L]]|0.415|
|[[:human genes:r:rabif|RABIF]]|0.413|
|[[:human genes:e:exoc2|EXOC2]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOC5 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>