EXOC6

Entrez Summary: N/A
UniProt Summary: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

exocyst
Flemming body
vesicle docking involved in exocytosis
Golgi to plasma membrane transport
vesicle docking
exocytic process
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
growth cone
organelle localization by membrane tethering
membrane docking
Golgi vesicle transport
organelle localization
perinuclear region of cytoplasm
exocytosis
secretion by cell
export from cell
secretion
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport
vesicle-mediated transport
membrane