EXOC6B

Entrez Summary: This gene encodes a protein which is a part of the evolutionarily conserved exocyst, a multimeric protein complex necessary for exocytosis, which in turn, is crucial for cell growth, polarity and migration. Disruption of this gene may be associated with phenotypes exhibiting multiple symptoms including intellectual disability and developmental delay (DD). [provided by RefSeq, Jun 2016].
UniProt Summary: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Salubrinal 20μM R07 exp399	-2.02
Momordin-Ic 10μM R08 exp506	-1.86

exocyst
vesicle docking involved in exocytosis
Golgi to plasma membrane transport
vesicle docking
exocytic process
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
organelle localization by membrane tethering
membrane docking
Golgi vesicle transport
organelle localization
exocytosis
secretion by cell
export from cell
secretion
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport
vesicle-mediated transport
membrane