EXOSC10

Gene Information

Official Symbol: EXOSC10
Official Name: exosome component 10
Aliases and Previous Symbols: N/A
Entrez ID: 5394
UniProt: Q01780
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Putative catalytic component of the RNA exosome complex which has 3'→5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 492/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	20/28
blood	14/28
bone	15/26
breast	19/33
central nervous system	39/56
cervix	3/4
colorectal	10/17
esophagus	9/13
fibroblast	1/1
gastric	11/16
kidney	15/21
liver	12/20
lung	50/75
lymphocyte	3/16
ovary	18/26
pancreas	18/24
peripheral nervous system	11/16
plasma cell	7/15
prostate	0/1
skin	22/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	20/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 492
Expression level (log2 read counts): 7.33

Expression Distribution

Screen	Score
AICAR 240μM R05 exp211	-1.98
MLN-4924 2μM R00 exp22	-1.87

HRDC
DNA pol A exo1
PMC2NT

nuclear polyadenylation-dependent CUT catabolic process
snRNA catabolic process
nuclear polyadenylation-dependent antisense transcript catabolic process
antisense RNA metabolic process
nuclear polyadenylation-dependent snRNA catabolic process
nuclear polyadenylation-dependent snoRNA catabolic process
antisense RNA transcript catabolic process
snoRNA catabolic process
nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
nuclear retention of unspliced pre-mRNA at the site of transcription
CUT metabolic process
CUT catabolic process
nuclear ncRNA surveillance
nuclear retention of pre-mRNA at the site of transcription
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent ncRNA catabolic process
polyadenylation-dependent ncRNA catabolic process
polyadenylation-dependent snoRNA 3-end processing
exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
polyadenylation-dependent RNA catabolic process
exonucleolytic trimming involved in rRNA processing
tRNA catabolic process
rRNA 3-end processing
intracellular mRNA localization
snoRNA 3-end processing
snoRNA processing
nuclear RNA surveillance
exoribonuclease activity
nuclear mRNA surveillance
histone mRNA catabolic process
RNA surveillance
dosage compensation by inactivation of X chromosome
nuclear exosome (RNase complex)
snoRNA metabolic process
exosome (RNase complex)
regulation of telomerase RNA localization to Cajal body
dosage compensation
rRNA catabolic process
negative regulation of telomere maintenance via telomerase