EXTL2

Gene Information

Official Symbol: EXTL2
Official Name: exostosin like glycosyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 2135
UniProt: Q9UBQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269|PubMed:10318803}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14817
Expression level (log2 read counts): 5.11

Expression Distribution

Screen	Score
TIC10 10μM R08 exp532	1.77
Etoposide 1μM R00 exp19	2.32

alpha-1,4-N-acetylgalactosaminyltransferase activity
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
UDP-N-acetylgalactosamine metabolic process
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
transferase activity, transferring glycosyl groups
N-acetylglucosamine metabolic process
glycosaminoglycan binding
glucosamine-containing compound metabolic process
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
nucleotide-sugar metabolic process
amino sugar metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
IRE1-mediated unfolded protein response
cellular carbohydrate biosynthetic process
manganese ion binding
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
endoplasmic reticulum unfolded protein response
aminoglycan biosynthetic process
cellular response to unfolded protein
carbohydrate biosynthetic process
cellular response to topologically incorrect protein
glycosaminoglycan metabolic process
response to unfolded protein
aminoglycan metabolic process
cellular carbohydrate metabolic process
response to topologically incorrect protein
response to endoplasmic reticulum stress
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process