EYA2 [The Human Chemical-Genetic Interaction Map Project]

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======= EYA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EYA2
  * **<color #00a2e8>Official Name</color>**: EYA transcriptional coactivator and phosphatase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2139|2139]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00167|O00167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EYA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EYA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601654|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone dephosphorylation|
|mesodermal cell fate specification|
|mesodermal cell fate commitment|
|mitochondrial outer membrane permeabilization|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of mitochondrial membrane permeability|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|mesodermal cell differentiation|
|cell fate commitment involved in formation of primary germ layer|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|apoptotic mitochondrial changes|
|positive regulation of DNA repair|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of mitochondrial membrane permeability|
|regulation of membrane permeability|
|cell fate specification|
|extrinsic apoptotic signaling pathway|
|positive regulation of response to DNA damage stimulus|
|protein tyrosine phosphatase activity|
|negative regulation of extrinsic apoptotic signaling pathway|
|peptidyl-tyrosine dephosphorylation|
|formation of primary germ layer|
|mesoderm development|
|regulation of DNA repair|
|mitochondrial membrane organization|
|regulation of extrinsic apoptotic signaling pathway|
|gastrulation|
|positive regulation of DNA metabolic process|
|protein dephosphorylation|
|magnesium ion binding|
|mitochondrial transport|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|cell fate commitment|
|striated muscle tissue development|
|apoptotic signaling pathway|
|muscle tissue development|
|dephosphorylation|
|transcription factor binding|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|DNA repair|
|tissue morphogenesis|
|embryonic morphogenesis|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|membrane organization|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|apoptotic process|
|embryo development|
|negative regulation of cell death|
|programmed cell death|
|chromosome organization|
|cell death|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.43|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.93|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.7|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EYA2 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>