EYA2

Gene Information

Official Symbol: EYA2
Official Name: EYA transcriptional coactivator and phosphatase 2
Aliases and Previous Symbols: N/A
Entrez ID: 2139
UniProt: O00167
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9902
Expression level (log2 read counts): -4.01

Expression Distribution

Screen	Score
Quercetin 20μM R08 exp517	-2.43
LJH685 50μM R08 exp433	-1.93
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.7
Hydroxyurea 100μM R07 exp329	1.83

histone dephosphorylation
mesodermal cell fate specification
mesodermal cell fate commitment
mitochondrial outer membrane permeabilization
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
positive regulation of mitochondrial membrane permeability
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of membrane permeability
mesodermal cell differentiation
cell fate commitment involved in formation of primary germ layer
extrinsic apoptotic signaling pathway in absence of ligand
signal transduction in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand
apoptotic mitochondrial changes
positive regulation of DNA repair
mesoderm formation
mesoderm morphogenesis
regulation of mitochondrial membrane permeability
regulation of membrane permeability
cell fate specification
extrinsic apoptotic signaling pathway
positive regulation of response to DNA damage stimulus
protein tyrosine phosphatase activity
negative regulation of extrinsic apoptotic signaling pathway
peptidyl-tyrosine dephosphorylation
formation of primary germ layer
mesoderm development
regulation of DNA repair
mitochondrial membrane organization
regulation of extrinsic apoptotic signaling pathway
gastrulation
positive regulation of DNA metabolic process
protein dephosphorylation
magnesium ion binding
mitochondrial transport
regulation of response to DNA damage stimulus
negative regulation of apoptotic signaling pathway