F11R [The Human Chemical-Genetic Interaction Map Project]

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======= F11R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F11R
  * **<color #00a2e8>Official Name</color>**: F11 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50848|50848]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y624|Q9Y624]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F11R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F11R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|V-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|slit diaphragm|
|establishment of endothelial intestinal barrier|
|intestinal absorption|
|establishment of endothelial barrier|
|bicellular tight junction assembly|
|tight junction assembly|
|regulation of actin cytoskeleton reorganization|
|positive regulation of blood pressure|
|tight junction organization|
|apical junction assembly|
|negative regulation of GTPase activity|
|endothelial cell development|
|digestive system process|
|virus receptor activity|
|regulation of membrane permeability|
|endothelial cell differentiation|
|PDZ domain binding|
|viral entry into host cell|
|endothelium development|
|entry into host cell|
|transforming growth factor beta receptor signaling pathway|
|entry into host|
|cell-cell junction assembly|
|digestion|
|actomyosin structure organization|
|bicellular tight junction|
|cell-cell junction organization|
|cellular response to transforming growth factor beta stimulus|
|interaction with host|
|response to transforming growth factor beta|
|cell junction assembly|
|cell-cell junction|
|regulation of blood pressure|
|protein localization to plasma membrane|
|epithelial cell development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|viral life cycle|
|cell junction organization|
|protein localization to cell periphery|
|cytoplasmic vesicle|
|cadherin binding|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|leukocyte migration|
|extracellular structure organization|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|positive regulation of GTPase activity|
|response to radiation|
|negative regulation of hydrolase activity|
|protein localization to membrane|
|regulation of GTPase activity|
|actin cytoskeleton organization|
|inflammatory response|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of cytoskeleton organization|
|cell junction|
|actin filament-based process|
|epithelial cell differentiation|
|regulation of cytokine production|
|viral process|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|cell migration|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|epithelium development|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|defense response|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|tissue development|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9046
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F11R Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>