F11R

Entrez Summary: N/A
UniProt Summary: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

slit diaphragm
establishment of endothelial intestinal barrier
intestinal absorption
establishment of endothelial barrier
bicellular tight junction assembly
tight junction assembly
regulation of actin cytoskeleton reorganization
positive regulation of blood pressure
tight junction organization
apical junction assembly
negative regulation of GTPase activity
endothelial cell development
digestive system process
virus receptor activity
regulation of membrane permeability
endothelial cell differentiation
PDZ domain binding
viral entry into host cell
endothelium development
entry into host cell
transforming growth factor beta receptor signaling pathway
entry into host
cell-cell junction assembly
digestion
actomyosin structure organization
bicellular tight junction
cell-cell junction organization
cellular response to transforming growth factor beta stimulus
interaction with host
response to transforming growth factor beta
cell junction assembly
cell-cell junction
regulation of blood pressure
protein localization to plasma membrane
epithelial cell development
transmembrane receptor protein serine/threonine kinase signaling pathway
viral life cycle
cell junction organization
protein localization to cell periphery
cytoplasmic vesicle