FABP1 [The Human Chemical-Genetic Interaction Map Project]

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======= FABP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FABP1
  * **<color #00a2e8>Official Name</color>**: fatty acid binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2168|2168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07148|P07148]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FABP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FABP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). {ECO:0000250|UniProtKB:P82289, ECO:0000269|PubMed:25732850}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|apical cortex|
|bile acid binding|
|positive regulation of fatty acid beta-oxidation|
|long-chain fatty acid transporter activity|
|positive regulation of fatty acid oxidation|
|regulation of fatty acid beta-oxidation|
|antioxidant activity|
|fatty acid binding|
|positive regulation of lipid catabolic process|
|triglyceride catabolic process|
|regulation of fatty acid oxidation|
|intestinal absorption|
|positive regulation of fatty acid metabolic process|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|peroxisomal matrix|
|glycerolipid catabolic process|
|regulation of lipid catabolic process|
|drug binding|
|long-chain fatty acid transport|
|cellular response to hydrogen peroxide|
|fatty acid transport|
|digestive system process|
|triglyceride metabolic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of fatty acid metabolic process|
|cellular oxidant detoxification|
|negative regulation of cysteine-type endopeptidase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|cellular detoxification|
|phospholipid binding|
|digestion|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|detoxification|
|cellular response to reactive oxygen species|
|monocarboxylic acid transport|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|regulation of cellular ketone metabolic process|
|cellular response to hypoxia|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|cellular response to decreased oxygen levels|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|lipid catabolic process|
|response to antibiotic|
|lipid localization|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|glycerolipid metabolic process|
|response to oxygen levels|
|response to oxidative stress|
|chromatin binding|
|regulation of lipid metabolic process|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|organic anion transport|
|response to toxic substance|
|response to inorganic substance|
|anion transport|
|protein-containing complex|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular lipid metabolic process|
|regulation of catabolic process|
|negative regulation of cell death|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|lipid metabolic process|
|regulation of hydrolase activity|
|ion transport|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.71|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.8|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.83|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.02|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FABP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>