FABP1

Entrez Summary: N/A
UniProt Summary: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). {ECO:0000250|UniProtKB:P82289, ECO:0000269|PubMed:25732850}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

apical cortex
bile acid binding
positive regulation of fatty acid beta-oxidation
long-chain fatty acid transporter activity
positive regulation of fatty acid oxidation
regulation of fatty acid beta-oxidation
antioxidant activity
fatty acid binding
positive regulation of lipid catabolic process
triglyceride catabolic process
regulation of fatty acid oxidation
intestinal absorption
positive regulation of fatty acid metabolic process
neutral lipid catabolic process
acylglycerol catabolic process
peroxisomal matrix
glycerolipid catabolic process
regulation of lipid catabolic process
drug binding
long-chain fatty acid transport
cellular response to hydrogen peroxide
fatty acid transport
digestive system process
triglyceride metabolic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of fatty acid metabolic process
cellular oxidant detoxification
negative regulation of cysteine-type endopeptidase activity
acylglycerol metabolic process
neutral lipid metabolic process
cellular detoxification
phospholipid binding
digestion
cellular response to antibiotic
response to hydrogen peroxide
detoxification
cellular response to reactive oxygen species
monocarboxylic acid transport
positive regulation of small molecule metabolic process
positive regulation of lipid metabolic process