FABP4 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= FABP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FABP4
  * **<color #00a2e8>Official Name</color>**: fatty acid binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2167|2167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15090|P15090]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FABP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FABP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hormone receptor binding|
|long-chain fatty acid binding|
|long-chain fatty acid transporter activity|
|cellular response to lithium ion|
|white fat cell differentiation|
|response to lithium ion|
|fatty acid binding|
|triglyceride catabolic process|
|brown fat cell differentiation|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|glycerolipid catabolic process|
|long-chain fatty acid transport|
|fatty acid transport|
|triglyceride metabolic process|
|cholesterol homeostasis|
|sterol homeostasis|
|lipid droplet|
|positive regulation of cold-induced thermogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|fat cell differentiation|
|lipid homeostasis|
|monocarboxylic acid transport|
|positive regulation of inflammatory response|
|regulation of cold-induced thermogenesis|
|cytokine production|
|cellular response to metal ion|
|cellular lipid catabolic process|
|cellular response to inorganic substance|
|negative regulation of protein kinase activity|
|cellular response to tumor necrosis factor|
|negative regulation of kinase activity|
|response to tumor necrosis factor|
|negative regulation of transferase activity|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|regulation of inflammatory response|
|response to metal ion|
|glycerolipid metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|organic anion transport|
|positive regulation of defense response|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|anion transport|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|response to bacterium|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular lipid metabolic process|
|regulation of transferase activity|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17681
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FABP4 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>