FABP4
Gene Information
- Official Symbol: FABP4
- Official Name: fatty acid binding protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 2167
- UniProt: P15090
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Lipocalin |
GO Terms
| hormone receptor binding |
| long-chain fatty acid binding |
| long-chain fatty acid transporter activity |
| cellular response to lithium ion |
| white fat cell differentiation |
| response to lithium ion |
| fatty acid binding |
| triglyceride catabolic process |
| brown fat cell differentiation |
| neutral lipid catabolic process |
| acylglycerol catabolic process |
| glycerolipid catabolic process |
| long-chain fatty acid transport |
| fatty acid transport |
| triglyceride metabolic process |
| cholesterol homeostasis |
| sterol homeostasis |
| lipid droplet |
| positive regulation of cold-induced thermogenesis |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| fat cell differentiation |
| lipid homeostasis |
| monocarboxylic acid transport |
| positive regulation of inflammatory response |
| regulation of cold-induced thermogenesis |
| cytokine production |
| cellular response to metal ion |
| cellular lipid catabolic process |
| cellular response to inorganic substance |
| negative regulation of protein kinase activity |
| cellular response to tumor necrosis factor |
| negative regulation of kinase activity |
| response to tumor necrosis factor |
| negative regulation of transferase activity |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| lipid catabolic process |
| lipid localization |
| regulation of inflammatory response |
| response to metal ion |
| glycerolipid metabolic process |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| organic anion transport |
| positive regulation of defense response |
| response to inorganic substance |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| anion transport |
| negative regulation of protein modification process |
| positive regulation of response to external stimulus |
| response to bacterium |
| regulation of defense response |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| cellular lipid metabolic process |
| regulation of transferase activity |
| cellular response to cytokine stimulus |
| negative regulation of cellular protein metabolic process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| lipid metabolic process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| homeostatic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Artemisinin 50μM R08 exp450 | 2.01 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17681
- Expression level (log2 read counts): -3.8
Expression Distribution
FABP4 Expression in NALM6 Cells: -3.8
