FABP5 [The Human Chemical-Genetic Interaction Map Project]

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======= FABP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FABP5
  * **<color #00a2e8>Official Name</color>**: fatty acid binding protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2171|2171]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01469|Q01469]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FABP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FABP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of retrograde trans-synaptic signaling by endocanabinoid|
|positive regulation of peroxisome proliferator activated receptor signaling pathway|
|regulation of prostaglandin biosynthetic process|
|regulation of unsaturated fatty acid biosynthetic process|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|negative regulation of glucose transmembrane transport|
|fatty acid binding|
|retinoic acid binding|
|triglyceride catabolic process|
|phosphatidylcholine biosynthetic process|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|regulation of fatty acid biosynthetic process|
|glycerolipid catabolic process|
|regulation of glucose transmembrane transport|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|regulation of fatty acid metabolic process|
|azurophil granule lumen|
|secretory granule membrane|
|positive regulation of cold-induced thermogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|glucose metabolic process|
|negative regulation of transmembrane transport|
|regulation of nervous system process|
|regulation of cold-induced thermogenesis|
|lipid binding|
|hexose metabolic process|
|regulation of cellular ketone metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|monosaccharide metabolic process|
|postsynaptic membrane|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|postsynaptic density|
|synapse|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|epidermis development|
|regulation of small molecule metabolic process|
|regulation of trans-synaptic signaling|
|carbohydrate metabolic process|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|cell junction|
|regulation of transmembrane transport|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|regulation of system process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.1|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.04|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.8|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.76|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.7|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.77|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.79|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.98|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.05|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6764
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FABP5 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>