FABP5

Entrez Summary: This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011].
UniProt Summary: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.1
Rotenone 2μM R00 exp33	-2.04
Nicotinamide Riboside 100μM R03 exp139	-1.8
BML-284 0.09μM R08 exp460	-1.76
CCT251545 0.2μM R06 exp271	1.7
S-trityl-L-cysteine 0.5μM R05 exp243	1.77
HMS-I2 5μM R06 exp287	1.79
AICAR 240μM R03 exp116	1.98
Torin1 0.08μM R02 exp82	2.05
IU1-47 25μM R04 exp182	2.51

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of retrograde trans-synaptic signaling by endocanabinoid
positive regulation of peroxisome proliferator activated receptor signaling pathway
regulation of prostaglandin biosynthetic process
regulation of unsaturated fatty acid biosynthetic process
regulation of peroxisome proliferator activated receptor signaling pathway
negative regulation of glucose transmembrane transport
fatty acid binding
retinoic acid binding
triglyceride catabolic process
phosphatidylcholine biosynthetic process
neutral lipid catabolic process
acylglycerol catabolic process
regulation of sensory perception of pain
regulation of sensory perception
regulation of fatty acid biosynthetic process
glycerolipid catabolic process
regulation of glucose transmembrane transport
triglyceride metabolic process
phosphatidylcholine metabolic process
regulation of fatty acid metabolic process
azurophil granule lumen
secretory granule membrane
positive regulation of cold-induced thermogenesis
acylglycerol metabolic process
neutral lipid metabolic process
glucose metabolic process
negative regulation of transmembrane transport
regulation of nervous system process
regulation of cold-induced thermogenesis
lipid binding
hexose metabolic process
regulation of cellular ketone metabolic process
glucose homeostasis
carbohydrate homeostasis
regulation of lipid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
monosaccharide metabolic process
postsynaptic membrane
glycerophospholipid biosynthetic process