FADD [The Human Chemical-Genetic Interaction Map Project]

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======= FADD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FADD
  * **<color #00a2e8>Official Name</color>**: Fas associated via death domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8772|8772]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13158|Q13158]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FADD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FADD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602457|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|DED|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|
|positive regulation of CD8-positive, alpha-beta T cell extravasation|
|regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation|
|negative regulation of activation-induced cell death of T cells|
|motor neuron apoptotic process|
|regulation of CD8-positive, alpha-beta T cell extravasation|
|positive regulation of T cell extravasation|
|regulation of activation-induced cell death of T cells|
|death effector domain binding|
|tumor necrosis factor receptor superfamily binding|
|TRAIL-activated apoptotic signaling pathway|
|regulation of T cell extravasation|
|CD95 death-inducing signaling complex|
|ripoptosome|
|necroptotic signaling pathway|
|receptor serine/threonine kinase binding|
|death-inducing signaling complex|
|death-inducing signaling complex assembly|
|caspase binding|
|toll-like receptor 3 signaling pathway|
|negative regulation of necroptotic process|
|negative regulation of programmed necrotic cell death|
|positive regulation of type I interferon-mediated signaling pathway|
|activation of cysteine-type endopeptidase activity|
|positive regulation of macrophage differentiation|
|death receptor binding|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|positive regulation of cellular extravasation|
|lymph node development|
|negative regulation of T cell apoptotic process|
|behavioral response to cocaine|
|regulation of programmed necrotic cell death|
|regulation of macrophage differentiation|
|positive regulation of activated T cell proliferation|
|necroptotic process|
|positive regulation of T cell mediated cytotoxicity|
|negative regulation of lymphocyte apoptotic process|
|programmed necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|regulation of necrotic cell death|
|regulation of cellular extravasation|
|necrotic cell death|
|tumor necrosis factor receptor binding|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|positive regulation of T cell migration|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of T cell mediated cytotoxicity|
|T cell homeostasis|
|regulation of T cell apoptotic process|
|response to isoquinoline alkaloid|
|spleen development|
|response to morphine|
|regulation of type I interferon-mediated signaling pathway|
|extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of activated T cell proliferation|
|positive regulation of lymphocyte migration|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|zymogen activation|
|regulation of T cell migration|
|neuron apoptotic process|
|thymus development|
|negative regulation of leukocyte apoptotic process|
|T cell differentiation in thymus|
|positive regulation of T cell mediated immunity|
|positive regulation of interleukin-8 production|
|positive regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cytokine-mediated signaling pathway|
|neuron death|
|regulation of lymphocyte apoptotic process|
|lymphocyte homeostasis|
|positive regulation of leukocyte mediated cytotoxicity|
|response to cocaine|
|positive regulation of myeloid leukocyte differentiation|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of response to cytokine stimulus|
|regulation of lymphocyte migration|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|leukocyte homeostasis|
|regulation of interleukin-8 production|
|regulation of T cell mediated immunity|
|cell body|
|regulation of leukocyte mediated cytotoxicity|
|response to anesthetic|
|cellular response to mechanical stimulus|
|regulation of leukocyte apoptotic process|
|positive regulation of tumor necrosis factor production|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of myeloid cell differentiation|
|positive regulation of T cell proliferation|
|extrinsic apoptotic signaling pathway|
|toll-like receptor signaling pathway|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|negative regulation of extrinsic apoptotic signaling pathway|
|protease binding|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|response to alkaloid|
|regulation of myeloid leukocyte differentiation|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|adult behavior|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of T cell proliferation|
|protein processing|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|response to ammonium ion|
|positive regulation of hemopoiesis|
|defense response to virus|
|positive regulation of peptidase activity|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|response to mechanical stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|protein maturation|
|membrane raft|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|T cell activation|
|lymphocyte differentiation|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|protein-containing complex binding|
|kidney development|
|regulation of leukocyte differentiation|
|response to virus|
|renal system development|
|apoptotic signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|urogenital system development|
|neuron projection|
|leukocyte differentiation|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|gland development|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|hemopoiesis|
|immune response-activating signal transduction|
|behavior|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|viral process|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.84|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.32|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|8.49|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|8.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:casp8|CASP8]]|0.693|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.682|
|[[:human genes:c:casp3|CASP3]]|0.652|
|[[:human genes:c:cxorf38|CXorf38]]|0.617|
|[[:human genes:m:mtmr4|MTMR4]]|0.538|
|[[:human genes:h:hnrnpl|HNRNPL]]|0.467|
|[[:human genes:z:zc3hav1|ZC3HAV1]]|0.458|
|[[:human genes:c:casp10|CASP10]]|0.454|
|[[:human genes:c:ccnc|CCNC]]|0.443|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.442|
|[[:human genes:f:fnip1|FNIP1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FADD Expression in NALM6 Cells: 3.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>