FADD
Gene Information
- Official Symbol: FADD
- Official Name: Fas associated via death domain
- Aliases and Previous Symbols: N/A
- Entrez ID: 8772
- UniProt: Q13158
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
- UniProt Summary: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225}.
Pfam Domains GO Terms
Pfam Domains
| Death |
| DED |
GO Terms
| positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation |
| positive regulation of CD8-positive, alpha-beta T cell extravasation |
| regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation |
| negative regulation of activation-induced cell death of T cells |
| motor neuron apoptotic process |
| regulation of CD8-positive, alpha-beta T cell extravasation |
| positive regulation of T cell extravasation |
| regulation of activation-induced cell death of T cells |
| death effector domain binding |
| tumor necrosis factor receptor superfamily binding |
| TRAIL-activated apoptotic signaling pathway |
| regulation of T cell extravasation |
| CD95 death-inducing signaling complex |
| ripoptosome |
| necroptotic signaling pathway |
| receptor serine/threonine kinase binding |
| death-inducing signaling complex |
| death-inducing signaling complex assembly |
| caspase binding |
| toll-like receptor 3 signaling pathway |
| negative regulation of necroptotic process |
| negative regulation of programmed necrotic cell death |
| positive regulation of type I interferon-mediated signaling pathway |
| activation of cysteine-type endopeptidase activity |
| positive regulation of macrophage differentiation |
| death receptor binding |
| negative regulation of necrotic cell death |
| regulation of necroptotic process |
| positive regulation of cellular extravasation |
| lymph node development |
| negative regulation of T cell apoptotic process |
| behavioral response to cocaine |
| regulation of programmed necrotic cell death |
| regulation of macrophage differentiation |
| positive regulation of activated T cell proliferation |
| necroptotic process |
| positive regulation of T cell mediated cytotoxicity |
| negative regulation of lymphocyte apoptotic process |
| programmed necrotic cell death |
| TRIF-dependent toll-like receptor signaling pathway |
| regulation of necrotic cell death |
| regulation of cellular extravasation |
| necrotic cell death |
| tumor necrosis factor receptor binding |
| extrinsic apoptotic signaling pathway in absence of ligand |
| signal transduction in absence of ligand |
| positive regulation of T cell migration |
| MyD88-independent toll-like receptor signaling pathway |
| regulation of T cell mediated cytotoxicity |
| T cell homeostasis |
| regulation of T cell apoptotic process |
| response to isoquinoline alkaloid |
| spleen development |
| response to morphine |
| regulation of type I interferon-mediated signaling pathway |
| extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of activated T cell proliferation |
| positive regulation of lymphocyte migration |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| zymogen activation |
| regulation of T cell migration |
| neuron apoptotic process |
| thymus development |
| negative regulation of leukocyte apoptotic process |
| T cell differentiation in thymus |
| positive regulation of T cell mediated immunity |
| positive regulation of interleukin-8 production |
| positive regulation of extrinsic apoptotic signaling pathway |
| positive regulation of cytokine-mediated signaling pathway |
| neuron death |
| regulation of lymphocyte apoptotic process |
| lymphocyte homeostasis |
| positive regulation of leukocyte mediated cytotoxicity |
| response to cocaine |
| positive regulation of myeloid leukocyte differentiation |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| positive regulation of response to cytokine stimulus |
| regulation of lymphocyte migration |
| positive regulation of interferon-gamma production |
| positive regulation of cell killing |
| leukocyte homeostasis |
| regulation of interleukin-8 production |
| regulation of T cell mediated immunity |
| cell body |
| regulation of leukocyte mediated cytotoxicity |
| response to anesthetic |
| cellular response to mechanical stimulus |
| regulation of leukocyte apoptotic process |
| positive regulation of tumor necrosis factor production |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of myeloid cell differentiation |
| positive regulation of T cell proliferation |
| extrinsic apoptotic signaling pathway |
| toll-like receptor signaling pathway |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of cell killing |
| negative regulation of extrinsic apoptotic signaling pathway |
| protease binding |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| response to alkaloid |
| regulation of myeloid leukocyte differentiation |
| pattern recognition receptor signaling pathway |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| T cell differentiation |
| positive regulation of leukocyte proliferation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| adult behavior |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of T cell proliferation |
| protein processing |
| regulation of adaptive immune response |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| response to ammonium ion |
| positive regulation of hemopoiesis |
| defense response to virus |
| positive regulation of peptidase activity |
| regulation of leukocyte migration |
| homeostasis of number of cells |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| response to mechanical stimulus |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| protein maturation |
| membrane raft |
| regulation of myeloid cell differentiation |
| negative regulation of apoptotic signaling pathway |
| innate immune response-activating signal transduction |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| T cell activation |
| lymphocyte differentiation |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| protein-containing complex binding |
| kidney development |
| regulation of leukocyte differentiation |
| response to virus |
| renal system development |
| apoptotic signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| response to xenobiotic stimulus |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| regulation of T cell activation |
| urogenital system development |
| neuron projection |
| leukocyte differentiation |
| cellular response to external stimulus |
| positive regulation of innate immune response |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| gland development |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| negative regulation of immune system process |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| hemopoiesis |
| immune response-activating signal transduction |
| behavior |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| viral process |
| regulation of proteolysis |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| regulation of cell migration |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| apoptotic process |
| leukocyte activation |
| defense response to other organism |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| response to organonitrogen compound |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| cell death |
| immune effector process |
| regulation of response to external stimulus |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of response to stress |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 20μM R00 exp26 | -1.84 |
| TNF-alpha 44ng/ml R08 exp533 | 2.32 |
| TRAIL 50ng/ml R00 exp36 | 8.49 |
| TRAIL 5ng/ml R00 exp35 | 8.49 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 18/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 3/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11109
- Expression level (log2 read counts): 3.64
Expression Distribution
FADD Expression in NALM6 Cells: 3.64
