FAH

Entrez Summary: This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF1969
FAA hydrolase

homogentisate metabolic process
homogentisate catabolic process
fumarylacetoacetase activity
tyrosine catabolic process
tyrosine metabolic process
arginine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
L-phenylalanine metabolic process
L-phenylalanine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
phenol-containing compound catabolic process
arginine metabolic process
benzene-containing compound metabolic process
glutamine family amino acid catabolic process
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
glutamine family amino acid metabolic process
organic hydroxy compound catabolic process
phenol-containing compound metabolic process
alpha-amino acid catabolic process
monocarboxylic acid catabolic process
cellular amino acid catabolic process
drug catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
small molecule catabolic process
aromatic compound catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
drug metabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process