FAM129B [The Human Chemical-Genetic Interaction Map Project]

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======= FAM129B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NIBAN2
  * **<color #00a2e8>Official Name</color>**: niban apoptosis regulator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64855|64855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96TA1|Q96TA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM129B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM129B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hypomethylation of CpG island|
|DNA hypomethylation|
|gonadotropin secretion|
|positive regulation of skeletal muscle fiber development|
|endocrine hormone secretion|
|regulation of skeletal muscle fiber development|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of DNA methylation|
|positive regulation of skeletal muscle tissue development|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of myotube differentiation|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of embryonic development|
|negative regulation of DNA biosynthetic process|
|negative regulation of Notch signaling pathway|
|endocrine process|
|regulation of skeletal muscle tissue development|
|regulation of transcription regulatory region DNA binding|
|positive regulation of DNA binding|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|adherens junction|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|hormone secretion|
|hormone transport|
|positive regulation of muscle cell differentiation|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of DNA biosynthetic process|
|negative regulation of vasculature development|
|negative regulation of DNA metabolic process|
|regulation of DNA binding|
|regulation of embryonic development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of cellular response to growth factor stimulus|
|regulation of muscle cell differentiation|
|signal release|
|positive regulation of binding|
|axon guidance|
|neuron projection guidance|
|regulation of cellular response to growth factor stimulus|
|transcription coactivator activity|
|regulation of angiogenesis|
|cadherin binding|
|regulation of vasculature development|
|regulation of DNA metabolic process|
|axonogenesis|
|regulation of binding|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of hormone levels|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|secretion by cell|
|neuron differentiation|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.86|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.76|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.91|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14779
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM129B Expression in NALM6 Cells: 0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>