FAM129B
Gene Information
- Official Symbol: NIBAN2
- Official Name: niban apoptosis regulator 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 64855
- UniProt: Q96TA1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| hypomethylation of CpG island |
| DNA hypomethylation |
| gonadotropin secretion |
| positive regulation of skeletal muscle fiber development |
| endocrine hormone secretion |
| regulation of skeletal muscle fiber development |
| negative regulation of vascular endothelial growth factor receptor signaling pathway |
| regulation of DNA methylation |
| positive regulation of skeletal muscle tissue development |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of myotube differentiation |
| regulation of vascular endothelial growth factor receptor signaling pathway |
| positive regulation of embryonic development |
| negative regulation of DNA biosynthetic process |
| negative regulation of Notch signaling pathway |
| endocrine process |
| regulation of skeletal muscle tissue development |
| regulation of transcription regulatory region DNA binding |
| positive regulation of DNA binding |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| adherens junction |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| hormone secretion |
| hormone transport |
| positive regulation of muscle cell differentiation |
| regulation of striated muscle cell differentiation |
| regulation of Notch signaling pathway |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| regulation of DNA biosynthetic process |
| negative regulation of vasculature development |
| negative regulation of DNA metabolic process |
| regulation of DNA binding |
| regulation of embryonic development |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| negative regulation of cellular response to growth factor stimulus |
| regulation of muscle cell differentiation |
| signal release |
| positive regulation of binding |
| axon guidance |
| neuron projection guidance |
| regulation of cellular response to growth factor stimulus |
| transcription coactivator activity |
| regulation of angiogenesis |
| cadherin binding |
| regulation of vasculature development |
| regulation of DNA metabolic process |
| axonogenesis |
| regulation of binding |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| regulation of hormone levels |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| neuron projection development |
| negative regulation of cell population proliferation |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| secretion by cell |
| neuron differentiation |
| export from cell |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK461364A 0.1μM R03 exp126 | -1.86 |
| QNZ 0.01μM R08 exp439 | 1.76 |
| 2-Deoxy-D-glucose 800μM R05 exp214 | 1.91 |
| RS-1 10μM R08 exp519 | 2.2 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.43 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14779
- Expression level (log2 read counts): 0.13
Expression Distribution
FAM129B Expression in NALM6 Cells: 0.13
