FAM132A

Gene Information

Official Symbol: C1QTNF12
Official Name: C1q and TNF related 12
Aliases and Previous Symbols: N/A
Entrez ID: 388581
UniProt: Q5T7M4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. {ECO:0000250|UniProtKB:Q8R2Z0}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13279
Expression level (log2 read counts): -1.69

Expression Distribution

negative regulation of gluconeogenesis
positive regulation of insulin receptor signaling pathway
positive regulation of cellular response to insulin stimulus
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of glucose import
negative regulation of cellular carbohydrate metabolic process
positive regulation of glucose transmembrane transport
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
regulation of glucose import
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of insulin receptor signaling pathway
positive regulation of insulin secretion
regulation of cellular response to insulin stimulus
regulation of glucose transmembrane transport
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
positive regulation of peptide hormone secretion
hormone activity
regulation of glucose metabolic process
positive regulation of hormone secretion
negative regulation of inflammatory response
regulation of cellular carbohydrate metabolic process
positive regulation of protein kinase B signaling
regulation of insulin secretion
positive regulation of transmembrane transport
regulation of carbohydrate metabolic process
negative regulation of defense response
regulation of peptide hormone secretion
regulation of protein kinase B signaling
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
regulation of inflammatory response
negative regulation of response to external stimulus
positive regulation of secretion by cell
positive regulation of protein transport
regulation of small molecule metabolic process
positive regulation of secretion
positive regulation of establishment of protein localization