FAM162A

Gene Information

Official Symbol: FAM162A
Official Name: family with sequence similarity 162 member A
Aliases and Previous Symbols: N/A
Entrez ID: 26355
UniProt: Q96A26
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269|PubMed:15082785}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3959
Expression level (log2 read counts): 5.83

Expression Distribution

positive regulation of release of cytochrome c from mitochondria
neuron apoptotic process
regulation of release of cytochrome c from mitochondria
neuron death
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrion organization
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
cellular response to hypoxia
positive regulation of peptidase activity
cellular response to decreased oxygen levels
cellular response to oxygen levels
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
response to hypoxia
response to decreased oxygen levels
positive regulation of proteolysis
response to oxygen levels
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
apoptotic process
programmed cell death
cell death
response to abiotic stimulus
positive regulation of cellular component organization
mitochondrion
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
regulation of apoptotic process