FAM172A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM172A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM172A
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 172 member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83989|83989]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUF8|Q8WUF8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM172A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM172A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arb2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin silencing by small RNA|
|siRNA binding|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|regulation of alternative mRNA splicing, via spliceosome|
|chromatin organization involved in regulation of transcription|
|neural crest cell development|
|negative regulation of gene expression, epigenetic|
|stem cell development|
|mesenchymal cell development|
|gene silencing by RNA|
|neural crest cell differentiation|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|gene silencing|
|mesenchymal cell differentiation|
|stem cell differentiation|
|mesenchyme development|
|regulation of gene expression, epigenetic|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|chromatin organization|
|RNA processing|
|endoplasmic reticulum|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cell development|
|RNA metabolic process|
|negative regulation of gene expression|
|tissue development|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.21|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.04|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.96|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.85|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.81|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.76|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.74|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.74|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.73|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.12|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM172A Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>