FAM172A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10μM R01 exp52	-2.21
Cannabidiol 13μM R08 exp465	-2.04
Thalidomide 20μM R07 exp406	-1.96
Resminostat 0.5μM R07 exp393	-1.85
BI-6727 0.001μM R01 exp42	-1.81
Adefovir 20μM R07 exp332	-1.76
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.74
Ibrutinib 1μM R07 exp372	-1.74
2-Methoxyestradiol 0.2μM R01 exp40	-1.73
Apcin 25μM plus proTAME 2μM R04 exp177	2.12
Quinacrine 2.5μM R03 exp146	2.17

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chromatin silencing by small RNA
siRNA binding
chromatin organization involved in negative regulation of transcription
chromatin silencing
regulation of alternative mRNA splicing, via spliceosome
chromatin organization involved in regulation of transcription
neural crest cell development
negative regulation of gene expression, epigenetic
stem cell development
mesenchymal cell development
gene silencing by RNA
neural crest cell differentiation
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
gene silencing
mesenchymal cell differentiation
stem cell differentiation
mesenchyme development
regulation of gene expression, epigenetic
regulation of mRNA metabolic process
RNA splicing
mRNA processing
mRNA metabolic process
chromatin organization
RNA processing
endoplasmic reticulum
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cell development
RNA metabolic process
negative regulation of gene expression