FAM21C [The Human Chemical-Genetic Interaction Map Project]

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======= FAM21C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASHC2C
  * **<color #00a2e8>Official Name</color>**: WASH complex subunit 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=253725|253725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4E1|Q9Y4E1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM21C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM21C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613631|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of barbed-end actin filament capping|
|retromer complex binding|
|regulation of barbed-end actin filament capping|
|protein localization to endosome|
|positive regulation of actin filament depolymerization|
|WASH complex|
|phosphatidylinositol-5-phosphate binding|
|positive regulation of protein depolymerization|
|phosphatidylinositol-3,5-bisphosphate binding|
|retrograde transport, endosome to plasma membrane|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|positive regulation of protein complex disassembly|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|regulation of actin filament depolymerization|
|regulation of substrate adhesion-dependent cell spreading|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of protein depolymerization|
|positive regulation of actin filament polymerization|
|retrograde transport, endosome to Golgi|
|vesicle-mediated transport to the plasma membrane|
|regulation of protein complex disassembly|
|positive regulation of protein polymerization|
|cytosolic transport|
|early endosome membrane|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|endosomal transport|
|positive regulation of protein complex assembly|
|early endosome|
|regulation of actin filament organization|
|endosome|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|regulation of cell morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|negative regulation of cellular component organization|
|protein localization to organelle|
|nucleolus|
|regulation of cell development|
|regulation of cellular component biogenesis|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7454
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM21C Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>