FAM21C
Gene Information
- Official Symbol: WASHC2C
- Official Name: WASH complex subunit 2C
- Aliases and Previous Symbols: N/A
- Entrez ID: 253725
- UniProt: Q9Y4E1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of barbed-end actin filament capping |
| retromer complex binding |
| regulation of barbed-end actin filament capping |
| protein localization to endosome |
| positive regulation of actin filament depolymerization |
| WASH complex |
| phosphatidylinositol-5-phosphate binding |
| positive regulation of protein depolymerization |
| phosphatidylinositol-3,5-bisphosphate binding |
| retrograde transport, endosome to plasma membrane |
| phosphatidylinositol-4-phosphate binding |
| phosphatidylinositol-3,4-bisphosphate binding |
| positive regulation of protein complex disassembly |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| phosphatidylinositol-3-phosphate binding |
| regulation of actin filament depolymerization |
| regulation of substrate adhesion-dependent cell spreading |
| phosphatidylinositol-4,5-bisphosphate binding |
| regulation of protein depolymerization |
| positive regulation of actin filament polymerization |
| retrograde transport, endosome to Golgi |
| vesicle-mediated transport to the plasma membrane |
| regulation of protein complex disassembly |
| positive regulation of protein polymerization |
| cytosolic transport |
| early endosome membrane |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of cell-substrate adhesion |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| endosomal transport |
| positive regulation of protein complex assembly |
| early endosome |
| regulation of actin filament organization |
| endosome |
| regulation of cell morphogenesis involved in differentiation |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| regulation of protein complex assembly |
| regulation of cell morphogenesis |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of organelle organization |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| negative regulation of cellular component organization |
| protein localization to organelle |
| nucleolus |
| regulation of cell development |
| regulation of cellular component biogenesis |
| regulation of anatomical structure morphogenesis |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7454
- Expression level (log2 read counts): 6.26
Expression Distribution
FAM21C Expression in NALM6 Cells: 6.26
