FAM3A

Gene Information

Official Symbol: FAM3A
Official Name: FAM3 metabolism regulating signaling molecule A
Aliases and Previous Symbols: N/A
Entrez ID: 60343
UniProt: P98173
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
UniProt Summary: May act as a defensin against invading fungal microorganisms.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17705
Expression level (log2 read counts): 4.87

Expression Distribution

Screen	Score
iCRT14 30μM R08 exp492	-3.3
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.77

negative regulation of antifungal innate immune response
regulation of antifungal innate immune response
regulation of defense response to fungus
antifungal humoral response
negative regulation of gluconeogenesis
defense response to fungus
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
response to fungus
negative regulation of innate immune response
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of small molecule metabolic process
negative regulation of response to biotic stimulus
regulation of carbohydrate biosynthetic process
antimicrobial humoral response
regulation of glucose metabolic process
regulation of cellular carbohydrate metabolic process
negative regulation of immune response
regulation of lipid biosynthetic process
regulation of carbohydrate metabolic process
negative regulation of defense response
negative regulation of multi-organism process
humoral immune response
negative regulation of response to external stimulus
regulation of lipid metabolic process
regulation of small molecule metabolic process
negative regulation of immune system process
cellular component
regulation of innate immune response
regulation of response to biotic stimulus
molecular function
regulation of defense response
regulation of multi-organism process
defense response to other organism
regulation of response to external stimulus
regulation of immune response
response to other organism
response to external biotic stimulus
response to biotic stimulus