FAM58A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM58A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNQ
  * **<color #00a2e8>Official Name</color>**: cyclin Q
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92002|92002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1B3|Q8N1B3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM58A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM58A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300708|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Activating cyclin for the cyclin-associated kinase CDK10. {ECO:0000269|PubMed:18297069, ECO:0000269|PubMed:24218572}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin-dependent protein serine/threonine kinase regulator activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of protein serine/threonine kinase activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of cell cycle|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-4.26|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-4.15|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-3.9|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-3.24|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-3.08|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.21|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.92|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.91|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.76|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.8|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.8|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.87|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.88|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.88|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.95|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.98|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.05|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.05|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.18|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.25|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.28|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.35|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.42|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.55|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.02|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.4|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.4|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|6.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ttc14|TTC14]]|0.721|
|[[:human genes:c:cdk10|CDK10]]|0.681|
|[[:human genes:r:rprd1b|RPRD1B]]|0.528|
|[[:human genes:c:ccnk|CCNK]]|0.502|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM58A Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>