FAM63B

Entrez Summary: N/A
UniProt Summary: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Milciclib 2μM R08 exp502	-1.82
UM131593 0.2μM R03 exp106	-1.78

K11-linked polyubiquitin modification-dependent protein binding
K6-linked polyubiquitin modification-dependent protein binding
cysteine-type carboxypeptidase activity
K48-linked polyubiquitin modification-dependent protein binding
Lys48-specific deubiquitinase activity
K63-linked polyubiquitin modification-dependent protein binding
protein K48-linked deubiquitination
thiol-dependent ubiquitin-specific protease activity
protein deubiquitination
protein modification by small protein removal
protein modification by small protein conjugation or removal
proteolysis