FAM83D

Entrez Summary: N/A
UniProt Summary: Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22. {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	-1.8
Mitomycin-C 0.06μM R08 exp503	-1.75

protein localization to mitotic spindle
mitotic spindle pole
protein localization to microtubule cytoskeleton
protein localization to cytoskeleton
kinesin binding
positive regulation of cell cycle G1/S phase transition
metaphase plate congression
epithelial to mesenchymal transition
establishment of chromosome localization
chromosome localization
positive regulation of cell cycle phase transition
regulation of TOR signaling
mesenchymal cell differentiation
regulation of cell cycle G1/S phase transition
nuclear chromosome segregation
mesenchyme development
microtubule binding
chromosome segregation
positive regulation of cell cycle process
regulation of ERK1 and ERK2 cascade
establishment of organelle localization
positive regulation of cell cycle
regulation of protein catabolic process
regulation of cell cycle phase transition
protein kinase binding
cell division
cell population proliferation
organelle localization
protein localization to organelle
regulation of MAPK cascade
regulation of cell cycle process
cell migration
regulation of catabolic process
cell cycle process
localization of cell
cell motility
regulation of cell cycle
locomotion
cell cycle
regulation of protein phosphorylation