FARP1

Entrez Summary: N/A
UniProt Summary: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rac guanyl-nucleotide exchange factor activity
dendrite morphogenesis
extrinsic component of cytoplasmic side of plasma membrane
Rho guanyl-nucleotide exchange factor activity
filopodium
cytoskeletal protein binding
synapse assembly
dendrite development
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of Rho protein signal transduction
dendritic spine
regulation of phosphatase activity
regulation of dephosphorylation
regulation of Ras protein signal transduction
synapse organization
regulation of small GTPase mediated signal transduction
cytoskeleton
dendrite
cell morphogenesis involved in neuron differentiation
negative regulation of hydrolase activity
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
cell junction
cell morphogenesis involved in differentiation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
neuron projection development
cell morphogenesis
negative regulation of catalytic activity
neuron development
cellular component morphogenesis
neuron differentiation
plasma membrane bounded cell projection organization
negative regulation of molecular function
cell projection organization
regulation of hydrolase activity
generation of neurons