FASTK

Entrez Summary: N/A
UniProt Summary: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.15
Isonicotinamide 500μM R03 exp129	1.7
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.94

Fas-activated serine/threonine kinase activity
regulation of RNA splicing
apoptotic signaling pathway
protein serine/threonine kinase activity
mitochondrial matrix
apoptotic process
protein phosphorylation
programmed cell death
cell death
phosphorylation
RNA binding
ATP binding