FAT1
Gene Information
- Official Symbol: FAT1
- Official Name: FAT atypical cadherin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2195
- UniProt: Q14517
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12065
- Expression level (log2 read counts): 7.49
FAT1 Expression in NALM6 Cells: 7.49
