FAT4

Entrez Summary: The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014].
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

condensed mesenchymal cell proliferation
regulation of metanephric nephron tubule epithelial cell differentiation
regulation of nephron tubule epithelial cell differentiation
ossification involved in bone maturation
mesenchymal cell proliferation
bone maturation
regulation of epithelial cell differentiation involved in kidney development
animal organ maturation
regulation of metanephros development
hippo signaling
inner ear receptor cell stereocilium organization
inner ear receptor cell development
branching involved in ureteric bud morphogenesis
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inner ear receptor cell differentiation
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of kidney development
mechanoreceptor differentiation
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
apical part of cell
nephron tubule development
fibroblast growth factor receptor signaling pathway
renal tubule development
kidney morphogenesis
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
mesonephros development
plasma membrane organization
nephron epithelium development
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
cerebral cortex development
nephron development
Notch signaling pathway
kidney epithelium development