FBF1

Entrez Summary: N/A
UniProt Summary: Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ciliary transition fiber
apical junction complex
establishment of epithelial cell polarity
apical junction assembly
ciliary basal body-plasma membrane docking
keratin filament
cell-cell junction assembly
establishment of cell polarity
spindle pole
ciliary basal body
cell-cell junction organization
centriole
cell junction assembly
organelle localization by membrane tethering
membrane docking
establishment or maintenance of cell polarity
cell junction organization
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
organelle localization
organelle assembly
plasma membrane bounded cell projection organization
cell projection organization