FBXL2

Gene Information

Official Symbol: FBXL2
Official Name: F-box and leucine rich repeat protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 25827
UniProt: Q9UKC9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). {ECO:0000250|UniProtKB:Q8BH16, ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:22323446, ECO:0000269|PubMed:23604317}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11369
Expression level (log2 read counts): 3.61

Expression Distribution

Screen	Score
GSK2606414 1μM R05 exp236	1.72
CCT251545 0.2μM R06 exp271	1.9

F-box
F-box-like

modulation by host of viral RNA genome replication
phosphatidylinositol 3-kinase regulatory subunit binding
modulation by host of viral genome replication
modulation by host of viral process
protein monoubiquitination
SCF ubiquitin ligase complex
modification by host of symbiont morphology or physiology
interaction with symbiont
protein phosphatase binding
regulation of viral genome replication
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
modification of morphology or physiology of other organism involved in symbiotic interaction
regulation of phosphatidylinositol 3-kinase signaling
regulation of viral life cycle
modification of morphology or physiology of other organism
calmodulin binding
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
ubiquitin-protein transferase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of autophagy
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
viral process
protein modification by small protein conjugation
regulation of multi-organism process
symbiotic process
interspecies interaction between organisms
regulation of cellular catabolic process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
regulation of catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process