FBXO32

Entrez Summary: N/A
UniProt Summary: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. {ECO:0000269|PubMed:15531760}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.75
CCCP 1μM R00 exp11	-1.71

response to denervation involved in regulation of muscle adaptation
response to muscle inactivity involved in regulation of muscle adaptation
response to muscle inactivity
response to inactivity
response to stimulus involved in regulation of muscle adaptation
cellular response to dexamethasone stimulus
response to dexamethasone
cellular response to glucocorticoid stimulus
cellular response to corticosteroid stimulus
SCF ubiquitin ligase complex
regulation of muscle adaptation
cellular response to ketone
response to antineoplastic agent
Z disc
response to glucocorticoid
response to corticosteroid
cellular response to xenobiotic stimulus
cellular response to steroid hormone stimulus
response to ketone
regulation of muscle system process
protein polyubiquitination
response to xenobiotic stimulus
response to steroid hormone
post-translational protein modification
cellular response to drug
cellular response to lipid
cellular response to organic cyclic compound
regulation of system process
cellular response to hormone stimulus
protein ubiquitination
protein modification by small protein conjugation
response to lipid
response to hormone
response to organic cyclic compound
protein modification by small protein conjugation or removal
response to drug
cellular response to oxygen-containing compound
cellular response to endogenous stimulus
response to endogenous stimulus
response to oxygen-containing compound